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Mycoplasma Genitalium

Mycoplasma test: the STI that gets missed

A mycoplasma test detects Mycoplasma genitalium, an STI that a standard chlamydia and gonorrhoea test does not pick up. The sample is usually urine or a swab, not blood. Many people have no symptoms, so the infection often goes unnoticed.

Doctor's Assessment Included

Mycoplasma Genitalium: what this test measures

This test uses polymerase chain reaction (PCR) technology to detect the DNA of Mycoplasma genitalium in a sample. PCR testing is the recommended diagnostic method for this organism, as Mycoplasma genitalium is extremely difficult to culture using standard laboratory techniques.

Some advanced testing panels may also include resistance markers, which help healthcare providers select the most effective antibiotic treatment. This is increasingly important given the growing prevalence of antibiotic-resistant strains.

Mycoplasma Genitalium: why this value matters

Mycoplasma genitalium is increasingly recognised as a significant sexually transmitted pathogen. When left untreated, it can cause persistent urethritis in men and cervicitis, endometritis, and pelvic inflammatory disease in women, potentially affecting fertility.

The rising prevalence of antibiotic resistance in Mycoplasma genitalium makes proper diagnosis and guided treatment essential. Standard antibiotic regimens for other STIs may not be effective against resistant strains, highlighting the importance of specific testing.

Mycoplasma Genitalium: when is testing worthwhile?

Testing is recommended for individuals with symptoms of urethritis (burning during urination, discharge), cervicitis, or persistent genital symptoms that have not responded to standard STI treatment. It may also be appropriate for those whose sexual partner has been diagnosed with Mycoplasma genitalium.

Consider testing if you have unexplained pelvic inflammatory disease or if standard treatment for chlamydia or gonorrhea has not resolved your symptoms. Your healthcare provider can advise whether Mycoplasma genitalium testing is appropriate for your situation.

Mycoplasma Genitalium: what to do about an abnormal value

Male

If Low

Not detected result indicates no Mycoplasma genitalium infection. Continue safe sexual practices.

If High

Detected result requires antibiotic treatment. Consider resistance-guided therapy for optimal outcomes.

Female

If Low

Not detected result indicates no Mycoplasma genitalium infection. Continue safe sexual practices.

If High

Detected result requires antibiotic treatment. Untreated infection may be associated with pelvic inflammatory disease. Consult your healthcare provider.

Mycoplasma Genitalium: lifestyle and this value

Consistent condom use is the primary prevention method for Mycoplasma genitalium. If diagnosed, it is crucial to complete the full course of prescribed antibiotics and to avoid sexual contact until treatment is confirmed successful, as incomplete treatment can contribute to antibiotic resistance.

Ensure your sexual partner is also tested and treated to prevent reinfection. Attend follow-up appointments to confirm the infection has cleared, as treatment failure is more common with Mycoplasma genitalium than with many other bacterial STIs due to antibiotic resistance.

Mycoplasma Genitalium: frequently asked questions

Is a mycoplasma test a blood test?

No. A Mycoplasma genitalium PCR test usually uses a urine sample or a swab, not blood. It detects the DNA of the bacteria.

Does a standard STI test find mycoplasma?

No. A standard STI test for chlamydia and gonorrhoea does not pick up Mycoplasma genitalium. That needs its own PCR test, which we cannot currently offer. If symptoms persist after treatment, discuss mycoplasma with your GP or the GGD.

How is Mycoplasma genitalium treated?

Mycoplasma genitalium is treated with antibiotics prescribed by a doctor. The bacteria are increasingly unresponsive to commonly used options, so a targeted choice matters and a follow-up test is often advised.

How soon after exposure can Mycoplasma genitalium be detected?

Usually from about 1 to 3 weeks after possible exposure. Testing too early can give a falsely negative result. A doctor can help you pick the right moment.